{"id":2271,"date":"2024-07-22T01:20:41","date_gmt":"2024-07-21T17:20:41","guid":{"rendered":"https:\/\/sunshineivf.com.tw\/?p=2271"},"modified":"2025-06-12T01:23:30","modified_gmt":"2025-06-11T17:23:30","slug":"hello-world-56","status":"publish","type":"post","link":"https:\/\/sunshineivf.com.tw\/en\/hello-world-56\/","title":{"rendered":"Telomere length &amp; telomerase activity in relation to egg cells"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"2271\" class=\"elementor elementor-2271\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3f9d0e71 e-flex e-con-boxed e-con e-parent\" data-id=\"3f9d0e71\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ffcc7b8 elementor-widget elementor-widget-text-editor\" data-id=\"ffcc7b8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div>Association of telomere length &amp; telomerase activity with IVF outcome in oocytes<\/div>\n<div>\u00a0<\/div>\n<div>Human oocyte TL is shortened during maturation<\/div>\n<div>TL is a better predictor of post IVF outcome than other parameters<\/div>\n<div>Cytoplasmic fragmentation-negative association in oocyte TL vs D3 pre-implantation embryos\u00a0<\/div>\n<div>TL length is associated with an aneuploid anomaly in humans.<\/div>\n<div>aneuploid blastocysts have longer TL &amp; lower TA\u00a0<\/div>\n<div>TL shortening is not associated with chromosome segregation errors in cleavage stage embryos<\/div>\n<div>TA is a better predictor of pregnancy outcome after IVF treatment than TL<\/div>\n<div>Oocyte TA Levels Predict Clinical Outcomes of IVF Therapy<\/div>\n<div>Higher TA levels positively correlate with clinical IVF outcomes<\/div>\n<div>Oocyte TL is associated with oocyte quality and embryo development.<\/div>\n<div>There is no direct correlation between TL function and reproductive potential, and oxidative DNA damage adversely affects IVF outcomes and early markers of clinical pregnancy<\/div>\n<div>TL abnormalities associated with ovarian insufficiency<\/div>\n<div>\u00a0Lower TA and shorter TL in oocytes associated with PCOS and longer infertility<\/div>\n<div>TA and TL Have No Prognostic Value for Embryo Quality and IVF Outcomes in Patients with PCOS<\/div>\n<div>Granulocyte TA is reduced in patients with ovarian insufficiency, and TL is shorter.<\/div>\n<div>IVF Women's TL Significantly Shorter<\/div>\n<div>https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC11224194\/<\/div>\n<div>\u00a0<\/div>\n<div>Studies focused on the relation between telomere length\/telomerase activity and oocytes<\/div>\n<div>\u00a0<\/div>\n<div>Human oocyte telomeres shorten during maturation<\/div>\n<div>TL provided a better predictor of outcome following IVF than other parameters<\/div>\n<div>Oocyte TL negatively predicted cytoplasmic fragmentation in D3 preimplantation embryos<\/div>\n<div>Telomere DNA length was associated with human aneuploidy development<\/div>\n<div>Aneuploid blastocysts have longer telomeres but lower TA when compared to either euploid or mosaic\/segmental human blastocysts<\/div>\n<div>Telomere shortening was not related to chromosome segregation errors in the cleavage stage embryo<\/div>\n<div>TA is a better predictor of pregnancy outcomes following IVF treatment than TL<\/div>\n<div>TA levels in luteinized GCs may predict the clinical outcomes of IVF treatment<\/div>\n<div>Higher TA levels were positively correlated with clinical IVF outcomes.<\/div>\n<div>TL in CCs is related to oocyte quality and embryo development<\/div>\n<div>No direct association of telomere function and reproductive potential, while oxidative DNA damage adversely affect early markers of IVF outcome and clinical pregnancies No direct association of telomere function and reproductive potential<\/div>\n<div>In young women, abnormal telomere homeostasis is linked to ovarian insufficiency<\/div>\n<div>\u00a0Lower TA and shorter TL in the GCs were linked with PCOS and a longer period of infertility<\/div>\n<div>No prognostic value for the TA and TL in terms of embryo quality and IVF outcomes in PCOS patients<\/div>\n<div>\u00a0Shorter LTL and GCTL in women with ovarian insufficiency compared with healthy controls<\/div>\n<div>- Diminished granular cell TA in patients with ovarian insufficiency compared with healthy controls<\/div>\n<div>Women undergoing IVF had statistically significant shorter telomeres compared to healthy controls.<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>Evaluation of telomere length (TL) and telomerase activity (TA) on predicting in vitro fertilization treatment outcomes<\/div>\n<div>\u00a0<\/div>\n<div><img decoding=\"async\" src=\"https:\/\/www.doing-housework.com\/store_image\/twivf\/file\/D1721612352091.jpg\" alt=\"\" \/><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u7c92\u7aeftelomere \u9577\u5ea6 &amp;\u00a0 \u7c92\u7aef\u9176telomerase\u6d3b\u6027 \u8207\u5375\u5b50\u7d30\u80de IVF\u7d50\u679c\u95dc\u806f\u6027 \u00a0 \u4eba [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2276,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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