{"id":2333,"date":"2024-09-30T01:53:29","date_gmt":"2024-09-29T17:53:29","guid":{"rendered":"https:\/\/sunshineivf.com.tw\/?p=2333"},"modified":"2025-06-12T01:54:39","modified_gmt":"2025-06-11T17:54:39","slug":"hello-world-67","status":"publish","type":"post","link":"https:\/\/sunshineivf.com.tw\/en\/hello-world-67\/","title":{"rendered":"The use of PGT does not significantly increase the cumulative pregnancy rate in the general population."},"content":{"rendered":"\t\t
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PGT\u4e4b\u4f7f\u7528\u4e26\u7121\u6cd5\u660e\u986f\u63d0\u5347\u4e00\u822c\u75c5\u60a3\u4e4b\u7d2f\u7a4d\u61f7\u5b55\u7387<\/div>\n
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Live Birth with or without Preimplantation Genetic Testing for Aneuploidy<\/div>\n
Published November 24, 2021<\/div>\n
N Engl J Med 2021;385:2047-2058<\/div>\n
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Embryo selection with preimplantation genetic testing for aneuploidy (PGT-A) may improve pregnancy outcomes after initial embryo transfer. However, it remains uncertain whether PGT-A improves the cumulative live-birth rate as compared with conventional in vitro fertilization (IVF).<\/div>\n
METHODS<\/div>\n
In this multicenter, randomized, controlled trial, we randomly assigned subfertile women with three or more good-quality blastocysts to undergo either PGT-A or conventional IVF; all the women were between 20 and 37 years of age. Three blastocysts were screened by next-generation sequencing in the PGT-A group or were chosen by morphologic criteria in the conventional-IVF group and then were successively transferred one by one. The primary outcome was the cumulative live-birth rate after up to three embryo-transfer procedures within 1 year after randomization. We hypothesized that the use of PGT-A would result in a cumulative live-birth rate that was no more than 7 percentage points higher than the rate after conventional IVF, which would constitute the noninferiority margin for conventional IVF as compared with PGT-A.<\/div>\n
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Download a PDF of the Research Summary.<\/div>\n
RESULTS<\/div>\n
A total of 1212 patients underwent randomization, and 606 were assigned to each trial group. Live births occurred in 468 women (77.2%) in the PGT-A group and in 496 (81.8%) in the conventional-IVF group (absolute difference, \u22124.6 percentage points; 95% confidence interval [CI], \u22129.2 to \u22120.0; P<0.001). The cumulative frequency of clinical pregnancy loss was 8.7% and 12.6%, respectively (absolute difference, \u22123.9 percentage points; 95% CI, \u22127.5 to \u22120.2). The incidences of obstetrical or neonatal complications and other adverse events were similar in the two groups.<\/div>\n
CONCLUSIONS<\/div>\n
Among women with three or more good-quality blastocysts, conventional IVF resulted in a cumulative live-birth rate that was noninferior to the rate with PGT-A. (Funded by the National Natural Science Foundation of China and others; ClinicalTrials.gov number, NCT03118141.)<\/div>\n
N Engl J Med<\/div>\n
. 2021 Nov 25;385(22):2047-2058.<\/div>\n
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PGT\u4e4b\u4f7f\u7528\u4e26\u7121\u6cd5\u660e\u986f\u63d0\u5347\u4e00\u822c\u75c5\u60a3\u4e4b\u7d2f\u7a4d\u61f7\u5b55\u7387 \u00a0 \u00a0 \u00a0 Live Birth with or withou […]<\/p>\n","protected":false},"author":1,"featured_media":2335,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[16,12],"tags":[],"class_list":["post-2333","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-16","category-12"],"_links":{"self":[{"href":"https:\/\/sunshineivf.com.tw\/en\/wp-json\/wp\/v2\/posts\/2333","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sunshineivf.com.tw\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sunshineivf.com.tw\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/en\/wp-json\/wp\/v2\/comments?post=2333"}],"version-history":[{"count":4,"href":"https:\/\/sunshineivf.com.tw\/en\/wp-json\/wp\/v2\/posts\/2333\/revisions"}],"predecessor-version":[{"id":2338,"href":"https:\/\/sunshineivf.com.tw\/en\/wp-json\/wp\/v2\/posts\/2333\/revisions\/2338"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/en\/wp-json\/wp\/v2\/media\/2335"}],"wp:attachment":[{"href":"https:\/\/sunshineivf.com.tw\/en\/wp-json\/wp\/v2\/media?parent=2333"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/en\/wp-json\/wp\/v2\/categories?post=2333"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/en\/wp-json\/wp\/v2\/tags?post=2333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}