{"id":2363,"date":"2024-10-24T15:14:09","date_gmt":"2024-10-24T07:14:09","guid":{"rendered":"https:\/\/sunshineivf.com.tw\/?p=2363"},"modified":"2025-06-12T15:15:04","modified_gmt":"2025-06-12T07:15:04","slug":"hello-world-72","status":"publish","type":"post","link":"https:\/\/sunshineivf.com.tw\/en\/hello-world-72\/","title":{"rendered":"Congratulations on the publication of SCI-ranked medical journal paper in collaboration with the National Applied Laboratory Research Laboratory."},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"2363\" class=\"elementor elementor-2363\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1a3822d2 e-flex e-con-boxed e-con e-parent\" data-id=\"1a3822d2\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-51349723 elementor-widget elementor-widget-text-editor\" data-id=\"51349723\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>abstract<\/h3>\n<p><strong>Half-dosage of gonadotropin-releasing hormone agonist is effective for pituitary desensitization during short IVF protocol.<\/strong><\/p>\n<div>Objectives: Gonadotropin-releasing hormone agonists (GnRHa) have been used for pituitary desensitization during Controlled Ovarian Hyperstimulation (COH)-In Vitro Fertilization (IVF) for decades. Hyperstimulation (COH)-In Vitro Fertilization (IVF) for decades. We aimed to determine the clinical differences between half and full-dosage We aimed to determine the clinical differences between half and full-dosage Leuprolide Acetate (LA) during short protocol COH-IVF.<\/div>\n<div>\u00a0<\/div>\n<div>Methods: All COH-IVF individuals were divided: (1) LA 0.5 mg\/day (age&lt;38, n=32); (2) LA 0.25 mg\/day (age&lt;38, n=38); (3) LA 0.5 mg\/day (age \u2265 38, n=30); (4) LA 0.25 mg\/day (age \u2265 38, n=33). The gonadropin dosage, Luteinizing Hormone (LH) surge, Ovarian Hyperstimulation Syndrome (OHSS) risk, oocyte and embryo number, Clinical Pregnancy Rate (CPR), and Live Birth Rate (LBR) were compared.<\/div>\n<div>\u00a0<\/div>\n<div>Results: We observed the non-significantly trends of lower gonadotropin dosages and higher LH surges in the halfdosage GnRHa groups compared to full- dosage GnRHa groups. Gonadotropin dosages (IU)\/E2 (pg\/mL) on human Chorionic Gonadotropin (hCG) day\/LH surges in each group were: (1) 1454.4\/1653.6\/ 0%; (2) 1419.6\/1683.5\/3%; (3) 1954.5\/910.8%\/0%; and (4) 1893.5\/953.6\/3.7% respectively. The oocyte number, day 3 embryo number, OHSS, and CPR were all higher in each group. number, OHSS, and CPR, LBR were non-statistically different between full and half LA groups. The oocyte number\/day 3 grade I, II embryo number\/CPR\/LBR in each group were: (1) 11.3\/5.6\/37.5%\/31.3%; (2) 11.8\/5.1\/39.4%\/33.3%, (3) 6.5\/2.6\/19.2%\/11.5%; and (4) 6.8\/2.7\/22.2%\/14.8%. TP3T\/14.8%.<\/div>\n<div>\u00a0<\/div>\n<div>Conclusions: Half-dosage GnRHa application results in comparable pituitary suppression and clinical outcomes compared to full-dosage GnRHa during short IVF protocol. The real roles of lower-dosage GnRHa upon pituitary desensitization during IVF warrant further investigation.<\/div>\n<div>\u00a0<\/div>\n<div>Author(s): Jen-Hsiang Hsieh, Yao-Yuan Hsieh, Chi-Chen Chang, Tsung-Tao Huang, Ming-Hua Shiao, Tzu-Chieh Kao, Chang-Wei Li<\/div>\n<div><a title=\"abstract\" href=\"https:\/\/www.biomedres.info\/abstract\/halfdosage-of-gonadotropinreleasing-hormone-agonist-is-effective-for-pituitary-desensitization-during-short-ivf-protocol-30466.html\" target=\"_blank\" rel=\"noopener\">abstract<\/a>\u00a0|\u00a0<a title=\"PDF\" href=\"https:\/\/www.biomedres.info\/biomedical-research\/halfdosage-of-gonadotropinreleasing-hormone-agonist-is-effective-for-pituitary-desensitization-during-short-ivf-protocol.pdf\">PDF<\/a><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Abstract Half-dosage of gonadotropin-releasing hormone  [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1952,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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