{"id":2177,"date":"2024-06-06T00:32:00","date_gmt":"2024-06-05T16:32:00","guid":{"rendered":"https:\/\/sunshineivf.com.tw\/?p=2177"},"modified":"2025-06-12T00:34:41","modified_gmt":"2025-06-11T16:34:41","slug":"hello-world-39","status":"publish","type":"post","link":"https:\/\/sunshineivf.com.tw\/zh\/hello-world-39\/","title":{"rendered":"\u6d3b\u52d5\u7cbe\u87f2\u7e3d\u6578\u91cftotal motile sperm count (TMC) \u8207\u4eba"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"2177\" class=\"elementor elementor-2177\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-29c4892a e-flex e-con-boxed e-con e-parent\" data-id=\"29c4892a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-280dcd41 elementor-widget elementor-widget-text-editor\" data-id=\"280dcd41\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div>\u6d3b\u52d5\u7cbe\u87f2\u7e3d\u6578\u91cftotal motile sperm count (TMC) \u8207\u4eba\u5de5\u53d7\u5b55\u61f7\u5b55\u7387PR\u6709\u95dc<\/div>\n<div>\u00a0<\/div>\n<div>TMC 15.1\u201320.0 million (\u61f7\u5b55\u738714.8%)<\/div>\n<div>\u00a0<\/div>\n<div>TMC \u22645 million (\u61f7\u5b55\u73875.5%))\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0Higher TMC was associated with greater live birth rate (TMC 15.1\u201320.0 million (14.8%) compared to \u22645 million (5.5%)) (aRR 2.09 (1.31\u20133.33)). However, live births did occur with TMC\u2009\u2264\u20091 million (5.1%).<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0time from hCG injection to IUI, sperm preparation method and ultrasound guidance for IUI were not associated with live birth success.<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>\u00a0<\/div>\n<div>Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples withunexplained infertility in a randomised, multicentre clinical trial\u00a0<\/div>\n<div>Human Reproduction, Volume 35, Issue 6, June 2020, Pages 1296\u20131305, https:\/\/doi.org\/10.1093\/humrep\/deaa027<\/div>\n<div>\u00a0<\/div>\n<div>Are intrauterine insemination (IUI) performance characteristics and post-processing total motile sperm count (TMC) related to live birth rate incouples with unexplained infertility?<\/div>\n<div>\u00a0<\/div>\n<div>SUMMARY ANSWER<\/div>\n<div>Patient discomfort with IUI and lower inseminate TMC were associated with a reduced live birth rate, while time from hCG injection to IUI, spermpreparation method and ultrasound guidance for IUI were not associated with live birth success.<\/div>\n<div>\u00a0<\/div>\n<div>WHAT IS ALREADY KNOWN<\/div>\n<div>We previously determined that some baseline characteristics of couples with unexplained infertility, including female age, duration of infertility,history of prior loss and income, were related to live birth rate across a course of ovarian stimulation and IUI treatment. However, the relationshipbetween treatment outcomes and per-cycle characteristics, including ultrasound guidance for IUI, timing of IUI relative to hCG injection, difficultor painful IUI and inseminate TMC, are controversial, and most prior investigations have not evaluated live birth outcome.<\/div>\n<div>\u00a0<\/div>\n<div>STUDY DESIGN, SIZE, DURATION<\/div>\n<div>This was a secondary analyses of 2462 cycles from the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) clinical trial.This prospective, randomised, multicentre clinical trial determined live birth rates following IUI after ovarian stimulation with clomiphenecitrate, letrozole or gonadotropins in 854 couples with unexplained infertility. It was conducted between 2011 and 2014, and couples could undergo up tofour consecutive treatment cycles.<\/div>\n<div>\u00a0<\/div>\n<div>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/div>\n<div>AMIGOS was an NIH-sponsored Reproductive Medicine Network trial conducted at 12 clinical sites. Participants were women with unexplained infertilitywho were between 18 and 40 years of age. Cluster-weighted generalised estimating equations (GEE), which account for informative clustering of multipleIUI treatment cycles within the same patient, were used to determine associations between IUI performance characteristics, including inseminate TMC,and live birth rate. Efficiency curves were also generated to examine the relationship between inseminate TMC and live birth rate.<\/div>\n<div>\u00a0<\/div>\n<div>MAIN RESULTS AND THE ROLE OF CHANCE<\/div>\n<div>After adjustment for treatment group and baseline factors previously associated with live birth across a course of OS-IUI treatment, patientdiscomfort during the IUI procedure was associated with a reduction in live birth rate (aRR 0.40 (0.16\u20130.96)). Time from hCG trigger injection to IUI was not significantly associated with outcome. Higher TMC was associated with greater live birth rate (TMC 15.1\u201320.0 million (14.8%) compared to \u22645 million (5.5%)) (aRR 2.09 (1.31\u20133.33)). However, live births did occur with TMC\u2009\u2264\u20091 million (5.1%).<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u6d3b\u52d5\u7cbe\u87f2\u7e3d\u6578\u91cftotal motile sperm count (TMC) \u8207\u4eba\u5de5\u53d7\u5b55\u61f7\u5b55\u7387PR\u6709\u95dc \u00a0 TM [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1952,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[14,12],"tags":[],"class_list":["post-2177","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-14","category-12"],"_links":{"self":[{"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/posts\/2177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/comments?post=2177"}],"version-history":[{"count":4,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/posts\/2177\/revisions"}],"predecessor-version":[{"id":2181,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/posts\/2177\/revisions\/2181"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/media\/1952"}],"wp:attachment":[{"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/media?parent=2177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/categories?post=2177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/tags?post=2177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}