{"id":2233,"date":"2024-07-08T01:04:42","date_gmt":"2024-07-07T17:04:42","guid":{"rendered":"https:\/\/sunshineivf.com.tw\/?p=2233"},"modified":"2025-06-12T01:06:16","modified_gmt":"2025-06-11T17:06:16","slug":"hello-world-49","status":"publish","type":"post","link":"https:\/\/sunshineivf.com.tw\/zh\/hello-world-49\/","title":{"rendered":"\u65b0\u7684\u5373\u6642\u6210\u50cf\u3001\u975e\u4fb5\u5165\u6027\u7d30\u80de\u6a19\u8a18\u6280\u8853"},"content":{"rendered":"
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\u00a0Labeling and live imaging of human embryos reveal that the majority of the future body originates, mostly, from one of the 2-cell stage blastomeres.Descendants of the first 2-cell stage blastomere to divide contribute more asymmetric divisions at the 8-cell stage, which generate the small number offounding epiblast cells before implantation.\u00a0<\/div>\n
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https:\/\/www.cell.com\/action\/showPdf?pii=S0092-8674%2824%2900455-0<\/a><\/div>\n
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The first two blastomeres contribute unequally to the human embryo\u00a0\u00a0<\/div>\n
https:\/\/doi.org\/10.1016\/j.cell.2024.04.029\u00a0<\/a><\/div>\n
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SUMMARY\u00a0<\/div>\n
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Retrospective lineage reconstruction of humans predicts that dramatic clonal imbalances in the body can be traced to the 2-cell stage embryo. However,whether and how such clonal asymmetries arise in the embryo is unclear. Here, we performed prospective lineage tracing of human embryos using liveimaging, non-invasive cell labeling, and computational predictions to determine the contribution of each 2-cell stage blastomere to the epiblast (body), hypoblast (yolk sac), and trophectoderm (placenta). We show that the majority of epiblast cells originate from only one blastomere of the 2-cell stage embryo. We observe that only one to three cells becomeinternalized at the 8-to-16-cell stage transition. Moreover, these internalized cells are more frequently derived from the first cell to divide at the 2-cell stage. We propose that cell division dynamics and a cell internalization bottleneck in the early embryo establish asymmetry in the clonalcomposition of the future human body.<\/div>\n
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