{"id":2265,"date":"2024-07-17T01:18:46","date_gmt":"2024-07-16T17:18:46","guid":{"rendered":"https:\/\/sunshineivf.com.tw\/?p=2265"},"modified":"2025-06-12T01:21:15","modified_gmt":"2025-06-11T17:21:15","slug":"hello-world-55","status":"publish","type":"post","link":"https:\/\/sunshineivf.com.tw\/zh\/hello-world-55\/","title":{"rendered":"\u65b0\u9bae ET \u5f8c\u61f7\u5b55\u7684 Fetal fraction (FF) \u751a\u81f3\u66f4\u4f4e"},"content":{"rendered":"
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\u8207\u51b7\u51cd\u80da\u80ce\u690d\u5165ET\u76f8\u6bd4\uff0c\u65b0\u9bae ET \u5f8c\u61f7\u5b55\u7684 Fetal fraction (FF) \u751a\u81f3\u66f4\u4f4e\uff0c\u9019\u53ef\u80fd\u53cd\u6620\u4e86\u8207\u81ea\u7136\u9031\u671f\u51b7\u51cd ET \u76f8\u6bd4\uff0c\u65b0\u9bae ET \u5f8c\u80ce\u9f61\u8f03\u5c0f\u7684\u50be\u5411\u3002<\/div>
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FF\u6578\u503c\u9ad8\u4f4e\u6bd4\u8f03: \u81ea\u7136\u61f7\u5b55>FET>fresh ET<\/div>
\u00a0<\/div>
\u96a8\u8457\u6bcd\u89aa BMI \u7684\u589e\u52a0\uff0cFF \u986f\u8457\u964d\u4f4e<\/div>
\u00a0<\/div>
significant reduction in the FF in ART patients compared with naturally conceived pregnancies, which seems to be more pronounced after fresh ET comparedwith frozen ET.<\/div>
a significant reduction in FF with increasing maternal BMI\u00a0<\/div>
Fetal fraction (FF) of cell-free DNA in pregnancies after fresh or frozen embryo transfer following assisted reproductive technologies\u00a0<\/div>
Human Reproduction, Volume 35, Issue 6, June 2020, Pages 1267\u20131275, https:\/\/doi.org\/10.1093\/humrep\/deaa110<\/div>
I<\/div>
\u00a0<\/div>
SUMMARY ANSWER<\/div>
This study shows a significant reduction in the FF in ART patients compared with naturally conceived pregnancies, which seems to be more pronounced afterfresh ET compared with frozen ET.<\/div>
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MAIN RESULTS AND THE ROLE OF CHANCE<\/div>
We found a reduction in FF in ART patients compared with naturally conceived pregnancies, and the reduction was more pronounced for ART pregnancies afterfresh ET (mean FF = 0.049) compared with frozen ET (mean FF = 0.063) (multivariate analysis adjusted for maternal BMI, P = 0.02). Another multivariate analysis, adjusted for BMI and multiples of median (MoM) values for pregnancy-associated plasma protein-A (PAPP-A),demonstrated a significantly reduced FF for ART pregnancies (mean FF = 0.056) compared with naturally conceived pregnancies (mean FF = 0.072) (P < 0.0001). We found that FF was significantly reduced with increasing maternal BMI (P < 0.0001) and with decreasing MoM values of PAPP-A (P = 0.003).<\/div>
\u00a0<\/div>
WIDER IMPLICATIONS OF THE FINDINGS<\/div>
Concurrent with other studies demonstrating a reduced FF for singleton pregnancies after ART treatment compared with naturally conceived pregnancies, we found a reduction in FF between the two groups. This is one of the first studies to examine FF in ART pregnancies after fresh ET compared with frozen ET,hence the existing knowledge is limited. We find that FF is even more reduced in pregnancies following fresh ET compared with frozen ET, which mightpossibly reflect the predisposition of being small for gestational age after fresh ET compared with natural cycle frozen ET.<\/div>
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\"\"<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

\u8207\u51b7\u51cd\u80da\u80ce\u690d\u5165ET\u76f8\u6bd4\uff0c\u65b0\u9bae ET \u5f8c\u61f7\u5b55\u7684 Fetal fraction (FF) \u751a\u81f3\u66f4\u4f4e\uff0c\u9019\u53ef\u80fd\u53cd\u6620\u4e86\u8207 […]<\/p>\n","protected":false},"author":1,"featured_media":2267,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[12,13],"tags":[],"class_list":["post-2265","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-12","category-13"],"_links":{"self":[{"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/posts\/2265","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/comments?post=2265"}],"version-history":[{"count":7,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/posts\/2265\/revisions"}],"predecessor-version":[{"id":2274,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/posts\/2265\/revisions\/2274"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/media\/2267"}],"wp:attachment":[{"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/media?parent=2265"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/categories?post=2265"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sunshineivf.com.tw\/zh\/wp-json\/wp\/v2\/tags?post=2265"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}