The use of preimplantation genetic testing for aneuploidy (PGT-A) has been steadily increasing. The underlying technology for 24-chromosome analysis continues to evolve rapidly.
The value of PGT-A as a routine screening test for all patients undergoing IVF has not been proven.
Although some early single-center studies reported higher rates of live births after PGT-A in patients with good prognosis
However, a recent multicenter randomized controlled trial of women with usable blastocysts concluded that
Overall pregnancy outcomes through frozen embryo transfer are similar between PGT-A.
The value of PGT-A in reducing the risk of clinical miscarriage is unknown.
Conclusion: The American Journal of Fertility still does not recommend the routine use of PGT for all IVF patients.
The use of preimplantation genetic testing for aneuploidy: a committee opinion
The use of preimplantation genetic testing for aneuploidy (PGT-A) in the United States has been increasing steadily. Moreover, the underlying technology used for 24-chromosome analysis continues to evolve rapidly. The use of preimplantation genetic testing for aneuploidy (PGT-A) in the United States has been increasing steadily. Moreover, the underlying technology used for 24-chromosome analysis continues to evolve rapidly. The value of PGT-A as a routine screening test for all patients undergoing in vitro fertilization has not been demonstrated. Although some earlier single-center studies reported higher live-birth rates after PGT-A in favorable-prognosis patients, recent multicenter, randomized control trials in women with available blastocysts concluded that the overall pregnancy outcomes via frozen embryo transfer were similar. The value of PGT-A to lower the risk of clinical miscarriage is also unclear, although there are some studies reporting higher live-birth rates after PGT-A in favorable-prognosis patients. The value of PGT-A to lower the risk of clinical miscarriage is also unclear, although these studies have important limitations. This document replaces the document of the same name, last published in 2018.
