Prolonged time between blastocyst slicing and freezing affects embryo implantation rate

 

Intervals longer than 1 hour significantly affect embryo survival and clinical outcomes 

 

 

 

Zygote

. 2021 Aug;29(4):276-281. doi: 10.1017/S0967199420000866. epub 2021 Feb 18.

 

Prolonged interval time between blastocyst biopsy and vitrification compromised the outcomes in preimplantation genetic testing

These cycles were divided into three groups according to the interval times: <1 h group, 1-2 h group, and ≥2 h group.

In PGT-A cycles, the clinical pregnancy and ongoing pregnancy rates in the 0.05) and the ≥2 h group (52.63%, 36.84%, P > 0.05). 

In conclusion, vitrification of blastocysts beyond 1 h after biopsy significantly influences embryo survival and clinical outcomes and is therefore not recommended.